Monday, September 19, 2011

Unraveling a new regulator of cystic fibrosis

Unraveling a new regulator of cystic fibrosis [ Back to EurekAlert! ] Public release date: 19-Sep-2011
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Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society

Bethesda, Md. (Sept. 19, 2011) Cystic fibrosis (CF), a chronic disease that clogs the lungs and leads to life-threatening lung infections, is caused by a genetic defect in a chloride channel called cystic fibrosis transmembrane conductase regulator (CFTR). Although scientists do not fully understand how or why this defect occurs, a team of researchers at The Hospital for Sick Children (SickKids) in Toronto, Ontario, Canada has found a promising clue: a protein called ubiquitin ligase Nedd4L.

In a study led by Daniela Rotin, PhD, senior scientist at SickKids and professor of biochemistry at the University of Toronto, mice specially bred to lack Nedd4L in the lung developed cystic fibrosislike lung disease. Dr. Rotin, the lead author of a number of recently published studies on this topic, will discuss the team's findings at the 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels conference sponsored by the American Physiological Society.

Previous studies have shown that CF results when a genetic mutation in CFTR interferes with its ability to deliver signals and instructions for cells to execute. In the case of the mutated gene, the lung cells absorb too much salt via a protein known as epithelial sodium channel (ENaC). Airways become dry and hamper the lungs' ability to clear away mucus and filter out foreign matter and bacteria. As a result, the person with CF becomes susceptible to debilitating infection and disease.

Nedd4L and ENaC

Previous CF research has shown that Nedd4L suppresses ENaC. To confirm the link, Dr. Rotin and her team genetically engineered mice to be born without Nedd4L in the lungs. The mice developed lung disease similar to cystic fibrosis, including inflammation and obstructed airways, and died within 3 weeks of birth. When the researchers sampled tissues from deceased mice, they found that there had been increased ENaC activity.

According to Dr. Rotin, the results indicate options for developing treatments for CF. "If you can enhance Nedd4L function or increase the amount of Nedd4L in the lungs, that may be useful in alleviating symptoms of the disease. Another option is to inhibit ENaC."

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About the Conference

The 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels explores the relationship between fluid regulation and hypertension, the cardiovascular system and other systems and is sponsored by the American Physiological Society. Additional information about the meeting can be found online at http://www.the-aps.org/press/releases/11/24.htm.

NOTE TO EDITORS: Dr. Rotin's presentation is entitled, "Deletion of the Ubiquitin Ligase Nedd4L in Lung Epithelia Causes Cystic Fibrosis-Like Disease." For an abstract of her presentation, or to request an interview, please contact Donna Krupa at 301.634.7209 or dkrupa@the-aps.org.

Physiology is the study of how molecules, cells, tissues and organs function to create health or disease. The American Physiological Society has been an integral part of the discovery process since it was established in 1887. To keep up with the science, follow @Phyziochick on Twitter.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Unraveling a new regulator of cystic fibrosis [ Back to EurekAlert! ] Public release date: 19-Sep-2011
[ | E-mail | Share Share ]

Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society

Bethesda, Md. (Sept. 19, 2011) Cystic fibrosis (CF), a chronic disease that clogs the lungs and leads to life-threatening lung infections, is caused by a genetic defect in a chloride channel called cystic fibrosis transmembrane conductase regulator (CFTR). Although scientists do not fully understand how or why this defect occurs, a team of researchers at The Hospital for Sick Children (SickKids) in Toronto, Ontario, Canada has found a promising clue: a protein called ubiquitin ligase Nedd4L.

In a study led by Daniela Rotin, PhD, senior scientist at SickKids and professor of biochemistry at the University of Toronto, mice specially bred to lack Nedd4L in the lung developed cystic fibrosislike lung disease. Dr. Rotin, the lead author of a number of recently published studies on this topic, will discuss the team's findings at the 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels conference sponsored by the American Physiological Society.

Previous studies have shown that CF results when a genetic mutation in CFTR interferes with its ability to deliver signals and instructions for cells to execute. In the case of the mutated gene, the lung cells absorb too much salt via a protein known as epithelial sodium channel (ENaC). Airways become dry and hamper the lungs' ability to clear away mucus and filter out foreign matter and bacteria. As a result, the person with CF becomes susceptible to debilitating infection and disease.

Nedd4L and ENaC

Previous CF research has shown that Nedd4L suppresses ENaC. To confirm the link, Dr. Rotin and her team genetically engineered mice to be born without Nedd4L in the lungs. The mice developed lung disease similar to cystic fibrosis, including inflammation and obstructed airways, and died within 3 weeks of birth. When the researchers sampled tissues from deceased mice, they found that there had been increased ENaC activity.

According to Dr. Rotin, the results indicate options for developing treatments for CF. "If you can enhance Nedd4L function or increase the amount of Nedd4L in the lungs, that may be useful in alleviating symptoms of the disease. Another option is to inhibit ENaC."

###

About the Conference

The 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels explores the relationship between fluid regulation and hypertension, the cardiovascular system and other systems and is sponsored by the American Physiological Society. Additional information about the meeting can be found online at http://www.the-aps.org/press/releases/11/24.htm.

NOTE TO EDITORS: Dr. Rotin's presentation is entitled, "Deletion of the Ubiquitin Ligase Nedd4L in Lung Epithelia Causes Cystic Fibrosis-Like Disease." For an abstract of her presentation, or to request an interview, please contact Donna Krupa at 301.634.7209 or dkrupa@the-aps.org.

Physiology is the study of how molecules, cells, tissues and organs function to create health or disease. The American Physiological Society has been an integral part of the discovery process since it was established in 1887. To keep up with the science, follow @Phyziochick on Twitter.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-09/aps-uan091911.php

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